As for the drugs, people should be careful since some folks may have cardio vascular issues that are unknown. Headaches are definitely a bad sign.

I know this because of the immunotherapy drugs for allergies due to having a horse farm. I found this out with the assistance of a doctor.

So be careful always .... you only have one life to live.

As for anal sex, I so want to try this with my partner.

I was also curious about this too, but honestly if I ever get the chance (current partner is a hell no), I want to feel the full process (lube of course).

Since my life experiences suck it would have to be pegging with a woman, or a transgender woman who was intact.

I mentally can't go there yet due to my rape with men even though I am pansexual.